Heart Health: Co Q10

 

 

Last time we talked about beginning your nutrient stack with a good multivitamin. As we continue our series on life extension, this time we will look at another Supplement for Longevity: Co Q10.

 

Co-enzyme Q10 is an antioxidant synthesized within the body that is found in all living cells. It is a vital ingredient for generating energy within the mitochondria, especially the heart and muscles. It also plays a role in oxygen utilization. Unfortunately, levels begin to decline in our 30's.

 

 

As levels of Co Q10 decrease in the body, the potential to develop many diseases increases. According to Dr. Weil, these risks include:
 

"angina, arrhythmia, heart failure and high blood pressure. Problems with blood sugar regulation, gingival (gum) health, and stomach ulcers have also been associated with CoQ10 deficiency. Those who are taking statins to lower cholesterol are at particular risk for deficiency, because not only do statins reduce cholesterol levels, but they also block CoQ10 synthesis in the body. Low CoQ10 levels in patients on statins can contribute to the common side effects of statin therapy such as fatigue and aching joints and muscles"

 

 

CoQ10 is found in many foods. Meats like beef, chicken and fish are the best sources. Sulfurous vegetables like broccoli and cauliflower are additional sources, as well as oils like canola and soybean, nuts and sesame seeds. Strawberries, spinach, sweet potatoes, sweet peppers, garlic, peas, and carrots contain a very small quantity that is not be to overlooked when trying to build a varied and balanced diet.

 

 

The University of Maryland Medical Center also reports on many of the heart benefits of CoQ10:

 

After Heart Attack

 

One clinical study found that people who took daily CoQ10 supplements within 3 days of a heart attack were less likely to have subsequent heart attacks and chest pain. They were also less likely to die of heart disease than those who did not take the supplements.

 

Heart failure (HF)

 

There is evidence that CoQ10 may help treat heart failure when combined with conventional medications. People who have congestive heart failure, where the heart is not able to pump blood as well as it should may also have low levels of CoQ10. Heart failure can cause blood to pool in parts of the body, such as the lungs and legs. It can also cause shortness of breath. Several clinical studies suggests that CoQ10 supplements help reduce swelling in the legs; reduce fluid in the lungs, making breathing easier; and increase exercise capacity in people with heart failure.

 

High blood pressure

 

Several clinical studies involving small numbers of people suggest that CoQ10 may lower blood pressure. However, it may take 4 to 12 weeks to see any change. In one analysis, after reviewing 12 clinical studies, researchers concluded that CoQ10 has the potential to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by 10 mm Hg, without significant side effects.

 

Diabetes

 

CoQ10 supplements may improve heart health and blood sugar and help manage high blood pressure in people with diabetes. Preliminary studies found that CoQ10 improves blood sugar control. But other studies show no effect. If you have diabetes, talk to your doctor or registered dietitian before taking CoQ10.

 

Heart damage caused by chemotherapy

 

Several clinical studies suggest that CoQ10 may help prevent heart damage caused by certain chemotherapy drugs, adriamycin, or other athracycline medications.

 

Heart surgery

 

Clinical research indicates that introducing CoQ10 prior to heart surgery, including bypass surgery and heart transplantation, can reduce damage caused by free radicals, strengthen heart function, and lower the incidence of irregular heart beat (arrhythmias) during the recovery phase.

 

 

Dosages

 

The Mayo Clinic offers several suggestions for Co Q10 dosages based on age and condition. Those recommendations are as follows:

 

Adults (18 years and older)

 

To treat Alzheimer's disease, 90-360 milligrams of idebenone (a man-made compound similar to CoQ10) has been taken by mouth daily in single or divided doses for 6-16 months. A dose of 400 milligrams of CoQ10 has been taken by mouth three times daily for 16 weeks.

 

To treat amyotrophic lateral sclerosis (ALS), 1,800 or 2,700 milligrams of CoQ10 has been taken by mouth daily in three divided doses for nine months. Doses of CoQ10 as high as 3,000 milligrams have been taken by mouth daily for eight months.

 

To treat chest pain, 60-600 milligrams of CoQ10 has been taken by mouth daily in single or divided doses for four weeks.

 

As an antioxidant, 60-150 milligrams of CoQ10 has been taken by mouth daily for 2-12 weeks. A dose of 30 milligrams of CoQ10 in oil or 20 milligrams of CoQ10 as a powder has been taken by mouth three times daily for two months. A dose of 100 milligrams of CoQ10 has been taken by mouth daily before hemodialysis over a six-month period.

 

To treat muscle control problems, 5-30 milligrams per kilogram of CoQ10 has been taken by mouth daily for 2-5 years. Doses of 300-3,000 milligrams of CoQ10 have been taken by mouth daily. A dose of 5 milligrams per kilogram of idebenone has been taken by mouth daily for up to five years.

 

To treat weakening of the heart muscle, 30-600 milligrams of CoQ10 has been taken by mouth daily for up to eight years. A dose of 2 milligrams per kilogram of CoQ10 has been taken by mouth in two or three divided doses along with regular heart medication, and increased to a maximum of 10 milligrams per kilogram by mouth daily for six months. A dose of 0.6 milligrams per kilogram has been taken by mouth daily for nine months.

 

To prevent heart disease, 200 milligrams of CoQ10 has been taken by mouth once daily for 12 weeks.

 

To treat side effects of chemotherapy, 50-90 milligrams of CoQ10 have been taken by mouth daily. An ointment containing ubiquinone has been applied to the skin. CoQ10 has been injected into the vein at a dose of 1 milligram per kilogram the day before anticancer treatment, on the day of treatment, and for two more days after treatment.

 

To treat coronary heart disease, 20-100 milligrams of CoQ10 have been taken by mouth three times daily for 4-8 weeks.

 

To treat type 1 diabetes, 100 milligrams of CoQ10 has been taken by mouth daily for 12 weeks.

 

To treat type 2 diabetes, 100 milligrams of CoQ10 has been taken by mouth twice daily for up to 12 weeks.

 

To improve exercise performance, doses of 50-300 milligrams of CoQ10 have been taken by mouth daily for up to 12 weeks. A dose of 100 milligrams or 300 milligrams of CoQ10 has been taken by mouth in two divided doses daily for one week, with one dose of three capsules on the morning of the eighth day prior to exercise.

 

To treat fibromyalgia, 300 milligrams of CoQ10 have been taken by mouth daily for nine months.

 

To improve blood vessel widening, 200 milligrams of CoQ10 have been taken by mouth daily for 12 weeks.

 

To treat gum disease, 5 milliliters of CoQ10 (200 milligrams per milliliter) in corn oil have been taken by mouth daily in divided doses. CoQ10 has been taken by mouth in soybean oil at a concentration of 85 milligrams per milliliter once per week for six weeks.

 

To treat hearing loss, 160-200 milligrams of have been taken by mouth once daily for 7-30 days. CoQ10 has been used as an 85 milligram per milliliter suspension in soybean oil and applied directly to the gum.

 

To treat heart attack, 120 milligrams of CoQ10 have been taken by mouth daily for a range of 28 days to one year. A dose of 250 milligrams of liquid CoQ10, followed by 150 milligrams of liquid CoQ10, have been given three times daily for five days through nasal tubes.

 

To treat chronic myocardial disease, 33 milligrams of CoQ10 has been taken by mouth three times daily for 12 weeks.

 

To treat heart failure, a dose of 2 milligrams per kilogram of CoQ10 has been taken by mouth daily for one year. Doses of 50-600 milligrams of CoQ10 have been taken by mouth daily for one month to 2 years.

 

To protect the heart during surgery, a dose of 100 milligrams of CoQ10 has been taken by mouth daily for 14 days before and 30 days after surgery. Doses of 30-200 milligrams of CoQ10 have been taken by mouth daily for 5-7 days before bypass surgery. A dose of 300 milligrams of CoQ10 have been taken by mouth daily for two weeks after surgery. A dose of 600 milligrams of CoQ10 has been taken by mouth in two divided doses at 6 p.m. the evening before the procedure and 6 a.m. the morning of the procedure. A dose of 150 milligrams of CoQ10 (in people weighing fewer than 60 kilograms) or 180 milligrams of CoQ10 (in people weighing more than 60 kilograms) has been taken by mouth in three divided doses daily for 7-10 days before surgery. A dose of 5 milligrams per kilogram of CoQ10 has been injected into the vein two hours before bypass surgery.

 

To treat hepatitis C, 40 milligrams or 80 milligrams of mitoquinone has been taken by mouth once daily with a glass of water following an overnight fasting period and a minimum of one hour before eating, for 28 days.

To treat HIV/AIDS, 200 milligrams of CoQ10 has been taken by mouth daily as a single dose or in three divided doses.

 

To treat Huntington's disease, 300-600 milligrams of CoQ10 has been taken by mouth daily for 120 weeks. A dose of 270 milligrams of idebenone (90 milligrams three times daily) has been taken by mouth daily for 52 weeks.

 

To treat high blood pressure, 60-360 milligrams of CoQ10 has been taken by mouth daily, with the average daily dose being 225 milligrams, for 8-12 weeks.

 

To treat heart disorders (left ventricular diastolic function), a dose of 20 milligrams of atorvastatin (Lipitor®) have been taken by mouth daily for 3-6 months and supplemented with 300 milligrams of CoQ10 daily (100 milligrams, three times daily) for an additional three months.

 

To lower cholesterol, 50-100 milligrams of CoQ10 has been taken by mouth daily for up to three months.

 

To treat male infertility, 30-300 milligrams of CoQ10 has been taken by mouth once daily or in divided doses for up to 26 weeks. 

 

To treat migraine, 150-300 milligrams of CoQ10 has been taken by mouth daily for up to three months. Doses of 1-3 milligrams per kilogram of CoQ10 have been taken by mouth in liquid gel capsules daily.

 

To treat mitochondrial diseases, 120-1,200 milligrams of CoQ10 has been taken by mouth daily for up to one year. A liquid form of CoQ10 has been taken by mouth at a dose of 5 milligrams per kilogram daily. A dose of 2 milligrams per kilogram of CoQ10 has been taken by mouth daily for six months.

 

To treat muscular dystrophies, 100 milligrams of CoQ10 has been taken by mouth daily.

 

To treat muscle disease caused by statins, 100-240 milligrams of CoQ10 (including Q-Sorb™) has been taken by mouth daily for up to 2.5 years.

 

To treat nerve pain of diabetes, 400 milligrams of CoQ10 has been taken by mouth daily for 12 weeks.

 

To treat Parkinson's disease, CoQ10 formulas have been taken by mouth in doses of 300-2,400 milligrams daily for four weeks to 16 months.

 

To treat Peyronie's disease (pain and curvature of penis), 300 milligrams of CoQ10 have been taken by mouth daily for a period of 24 weeks.

 

To treat high blood pressure of pregnancy, 100 milligrams of CoQ10 has been taken by mouth twice daily, a total of about 20-24 weeks.

 

To treat kidney failure, 180-200 milligrams of CoQ10 have been taken by mouth daily for up to eight weeks.

 

To promote weight loss, 100 milligrams of CoQ10 has been taken by mouth daily for three months.

 

For anti-aging purposes, a 1 percent CoQ10 cream has been applied to the skin for five months.

 

 

Conclusion

 

I believe an ideal supplemental dosage of CoQ10 for those with a family history of heart problems, or who have other risks for cardiovascular disease, and want to prevent age related decline is 100mg. This is an easily available dose that is cost effective in any life extension or longevity regimen. CoQ10 is fat-soluble, so its best to take it with a meal containing fats or oils.

 

 

 

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